2015
09.29

サンパウロボリビアというブラジルに存在する蜂のハチ毒ががん細胞を攻撃することが分かりました

コラム

Getting stung by the Brazilian wasp Polybia paulista may not be such a bad thing if you have cancer, research suggests.

The social wasp’s venom contains a powerful “smart” drug that selectively targets and destroys tumour cells without harming normal cells, a study has shown.

In laboratory tests, it has been shown to suppress the growth of prostate and bladder cancer cells – as well as multi drug-resistant leukaemia cells.

New research has now revealed the secret of the venom toxin, known as MP1. Scientists found that it blows gaping holes in the protective membranes surrounding tumour cells by interacting with fatty molecules called lipids.

Researcher Dr Paul Beales, from the University of Leeds, said: “Cancer therapies that attack the lipid composition of the cell membrane would be an entirely new class of anticancer drugs.

“This could be useful in developing new combination therapies, where multiple drugs are used simultaneously to treat a cancer by attacking different parts of the cancer cells at the same time.”

The unique way certain lipids are embedded on the outside of cancer cell membranes makes tumours susceptible to the wasp toxin, the researchers found.

In healthy cells, the same structural molecules are located on the inner membrane surface.

When MP1 binds to the lipids, it disrupts the membrane structure – creating large holes through which molecules vital to a cancer cell’s survival leak out.

Co-author Dr Joao Neto, from Sao Paulo State University in Brazil, said: “Formed in only seconds, these large pores are big enough to allow critical molecules such as RNA and proteins to easily escape cells.”

Future studies will examine MP1’s structure in more detail and attempt to improve its selectivity and potency.

Dr Beales said the laboratory tests suggested that the molecule was harmless to healthy cells and therefore safe, but added: “Further work would be required to prove that.”

The findings are published in the Biophysical Journal.

スクリーンショット 2015 09 29 6 20 56

https://home.bt.com/news/odd-news/brazilian-wasp-sting-could-help-battle-against-cancer-11364001320370

 

サンパウロボリビアというブラジルに存在する蜂のハチ毒ががん細胞を攻撃することが分かりました。

このM1というハチ毒の一部にがん細胞だけを攻撃し、通常細胞(健康な細胞)は無害という効果があることが分かりました。がん細胞に対しては穴を開けるそうです。

 

これはがん治療にかなりの効果を発揮しそうですね。

癌という病気に対し、研究が進むのは儲かるか儲からないかの違いです。癌になりやすい病気例えば胃がん、大腸がんなどはどんどん研究されています。一方で癌になると死亡率が高いですがなかなか癌としてはなりにくいという胆管癌などの研究はあまり進んでいません。

この様にがんの研究は密接に収入に関係しているのです。

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